THE
RESULTS SO FAR
VIRAL ANTIBODY SCREEN
All results were negative apart from a finding of a recent acute infection
from the Epstein Barr virus (glandular fever) which showed up positively
to one of these antigens. This could indicate a suppressed immune system.
I shall be conducting tests for streptococcus and chicken pox as he has
had both viral strains and may show antibodies to these if still active.
ENDOCRINOLOGY
IgG allergy screen for casein and gluten. Comments: These results observed
are in favour of an immune reaction against these allergens, but no normal
values have ever been determined. These results may be considered as an
argument in favour of a food sensitisation in case of clinical food intolerance.
(This confirmed that the allergy tests we had done were accurate
I shall mention those a little later on.)
BIOCHEMISTRY
This looks predominantly at liver function and how stressed it may be.
The results show Billy was extremely high in alkaline phosphatase with
a measured value of 217 IU/L against the normal range of 3095, and
asparate transferase with a value of 52 IU/L against a range of 1035.
This indicates a stressed liver. I am looking further into this at the
moment.
TESTS
STILL TO BE COMPLETED
LYMPHOCYTE IMMUNOPHENOTYPE
The laboratory was not able to complete this test due to a technical problem,
so we shall have to re-run it. I shall ask for the following to be observed:
1 Natural Killer cells 2 T cells 3 B cells
4 Total immunoglobulin for IgA, IgE, IgG 1, IgG 2, IgG 3, IgG 4
BIOCHEMISTRY
Mercury (showed negative exposure). I shall be conducting other biochemistry
tests for aluminium, zinc, manganese and magnesium.
BLOOD COUNT
All normal. I am awaiting blood test results from Dr Singh in the USA
to see if there are antibodies present to myelin protein
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URINE
ANALYSIS
URINE
ANALYSIS
The organic acid test was completed by The Great Plains Laboratory in
the United States. The test primarily looks at metabolites associated
with the presence of intestinal yeast or bacteria passing from the gut
into the blood and excreted through the urine. The test also reveals nutritional
and antioxidant deficiencies, inborn errors of metabolism, amino acid
or fatty acid problems, exposure to solvent toxins, deficiencies of B
and C vitamins and unusual levels of neurotransmitters. Dr Shaw provided
a complete interpretation and treatment suggestions with all of the results
returned. This test also suggests treatment with anti-fungals, dietary
supplementation and dietary modification.
RESULTS
We found Billy had elevated yeast/fungal metabolites which indicate an
overgrowth in the gastro intestinal tract and also a bacterial overgrowth.
Low hippuric levels suggested a depletion of glycine by competing detoxification
reactions in fatty acid oxidation disorders, (again reconfirming the psionic
test results). Increased citric since the enzyme needed to metabolise
citric is dependent on glutathione a biochemical derived from cysteine,
again a link with the poor utilisation of this very important amino acid.
Elevated kynurenic, a tryptophan metabolite that requires vitamin B6 for
its further metabolism possible B6 deficiency? We ran the same
tests for myself, Bella and Tobias and from the results, especially the
children, they came up with virtually the same identical abnormalities.
ALLERGY
TESTS
RESULTS
Both of the boys were allergy tested in their earlier days, Billy was
18 months old and Tobias was only six months. Findings showed the following
food allergy or intolerances.
BILLY
wheat, rye, barley, chicken, eggs, beef, pig, azodye,s tap water.
TOBY
wheat, rye, barley, chicken, eggs, beef, azodyes, tap water, onion, garlic,
tomatoes, peppers, aubergines.
These
results are interesting and one common element is clear. Cysteine is found
in the following foodstuffs: egg yolks, poultry, yogurts, oats, wheatgerm,
garlic, onions, broccoli, and brussels sprouts. Both our boys cannot eat
65% of the foodstuffs in which cysteine is present. So is there a link
between food allergy/intolerance and the foodstuffs that contain cysteine?
The boys have reacted to these allergens even though Tobias, and pretty
much Billy, were not exposed to these foodstuffs. This therefore is not
a classic allergy unless the motheršs antibodies have been passed to the
child during pregnancy, or it is in the genes and becomes a metabolic
disorder inherited from either parent. Is it the gene that may be responsible
for a certain enzyme not being produced to carry out its function? If
there are one or more enzyme deficiencies, certain amino acids such as
cysteine may not be metabolised sufficiently to produce bio-chemicals
such as lipoic acid, glutathione co-enzyme A, heparin and biotin. Help!
Someone please explain.
STOOL
ANALYSIS
We
have also had two stool tests completed. One by Parascope in Leeds to
look at possible parasitic infection and the other by The Great Smokies
Laboratory in the USA who completed a comprehensive stool analysis.
RESULTS
Parascope found elevated 3+ levels in two parasites: Blastocystis hominis
and dientamoeba fragilis. The Great Smokies Laboratory also ran a parasitology
test and found elevated levels in both blastocystis hominis and dientamoeba
fragilis plus trophozoites. They made the following comments:
Blastocystis hominis is considered by most authorities to be a pathogen.
It often lodges within the intestinal mucosa making eradication difficult.
Symptoms may include sleeplessness, irritable/inflamed bowel and fever,
although asymptomatic infections can occur.
Dientamoeba fragilis is a pathogenic flagellate. The organism usually
resides in the caecum and proximal colon and symptoms may include diarrhoea,
abdominal tenderness and weight loss.
The Great Smokies Laboratory also looked at his digestion, absorption,
microbiology, metabolic markers, mycology and immunology and made the
following comments relating to each:
DIGESTION
Meat fibres and the putrefactive short chain fatty acids valerate (iso
and n) and iso-butyrate are above the reference range. This pattern suggests
Protein malabsorptive and maldigestive.
Elevated meat and vegetable fibres are indirect indicators of maldigestion
due to hydrochloric acid/pepsin insufficiency, pancreatic enzyme insufficiency
and a rapid transit time.
QUESTIONS: I commented in
the first issue of The Autism File that whilst travelling on holiday,
Billys vomit resembled albumin if it was mucus in the stomach
and he did not have a trace of a cold could this be present due to insufficient
acid in his stomach? If so, does this link with the poor digestion of
proteins and the suppressed release of secretin and thereafter pancreatic
enzymes? Could secretin have triggered the release of pancreatic enzymes
from the blood born side rather than the gut side? Elevations in putrefactive
short chain fatty acids generally indicate inadequate protein digestion
in the small intestine. Paul Shattock research data shows absorbed gluten
and casein peptides result in fermentation of proteins in the large intestine.
Poor protein digestion may be associated with inadequate mastication (chewing),
increased protein intake, hypo or achlorhydria, inadequate proteolytic
enzyme or malabsorption.
ABSORPTION
All markers were in the reference range.
MICROBIOLOGY
Lactobacilla and bifidobacteriaI were found in lower then optimal levels.
These are important for gastrointestinal function as they are involved
in vitamin synthesis, natural antibiotic production, immune defence, digestion,
detoxification of pro-carcinogens and a host of other activities. Imbalanced
gut flora may occur as a result of a parasite or bacterial infection,
yeast overgrowth or poor nutrition and maldigestion all of which
Billy has!
MYCOLOGY
It may reflect a yeast overgrowth (also found in his urine metabolites)
and may lead to symptoms showing deficient beneficial bacteria.
METABOLIC
All metabolic markers are within the reference range.
IMMUNOLOGY
Secretory IgA (S-IgA) is within the normal range. As this is normal does
it indicate that there is no viral infection of the GI Tract?
As you can see from only doing what I feel are the basic tests I have
got some very precise and interesting data. I see these results as identifying
problems that can easily be treated. This is what we started on 7 November
1999. All samples were taken prior to any treatments as these would possibly
lead to confusion with some of the results. We did not do Paul Shattocks
urinary peptide test as Billy has been off gluten and casein for 20 months.
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THE
TREATMENTS
PARASITIC
CONTROL
Citramesia
YEAST/FUNGAL OVERGROWTH
Amphotericin B (Fungizone brand, from France). After three weeks we will
introduce diflucan (systemic anti-fungal).
SUPPLEMENTATION
l Super Nu Thera*
l Colostrum Gold*
l Trinethyglyline*
l Methylsulfonglmethane*
* From Kirkman Labs, www.kirkmanlabs.com
We are currently about to introduced ambritose, phyt-aloe and sea-cure
(from Mannetech, www. mannetech.com).
FOR GUT FLORA
Lactobacillus acidophillus and Se Fos - Fructooligosaccarides
We have already seen major improvements in Billy. His eye contact is excellent
and his speech is much more spontaneous. Hes happy, alert and playing
well with his brother, sister and classmates. His teacher has commented,
Whatever hes on keep it going. Hes brilliant
at the moment. Initially, however, after six days he was looking
yellowish and his behaviour and compliance went off the scale. This was
most likely the herxheimer reaction or what is more commonly known as
the die off. Yeast cells explode and their contents, ie toxins,
are released into the blood stream and stress
the liver.
Yet more testing times ahead
I still have to finish my diagnostic testing protocol and I must look
at finding any abnormalities with sulphate levels in his urine, hydrochloric
acid and pepsin levels in his stomach. Ill complete all tests probably
every 6-8 weeks to check his progress and change treatment protocols if
necessary.
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