ALLERGY RESEARCH FOUNDATION CONFERENCE
18 NOVEMBER 2020
AT THE MEDICAL SOCIETY OF LONDON
Paediatrician at Frimley Park Hospital
Dr Tettenborn has treated a number of autistic children with anti-fungal
and dietary intervention. In a study on 57 children at an average age
of four and one month, with a average onset of autism at
months, he completed the following treatments
Had no treatment
Had anti-fungal therapy
Were put on a gluten/casein free diet
Had anti-fungal therapyand gluten free diet
those treated 28 showed a marked improvement
He found that when using anti-fungals the child can often get worse before
they start to improve. His cases were completed on children who fell within
the following classifications:
clear history of onset of regression in the second year of life
eye contact and finger pointing prior to regression
history of altered bowel habits
history of illness at the onset of regression
thirst craving milk and wheat
pale face, dark shadows under the eyes
abdomen and increased flatus
comments: These are children that, due to their physical conditions and
health history are perfect cases for anti-fungal and dietary
modifications. They are probably allergic to a number of foodstuffs and
have a gastro-intestinal yeast overgrowth. I need to enquire of Dr Tettenborn
whether he completes organic-acid and urinary peptide tests to confirm
the presence of yeast overgrowth before using this treatment protocol.
Low diet in refined sugars, yeasts and fermented products
Oral nystatin (anti-fungal) or amphotericin in a sugar free suspension
for four months
He then adjusts the dose according to response
Treatment with floconazole, a systemic antifungal (23 mg/kg once
daily for three weeks also helps)
My comments: Using anti-fungals is great. In Billys case I completed
a liver function test before treatment and will do another test mid treatment
to see if his liver is stressed by such treatment, especially if using
systemic anti-fungal therapy. The Great Smokies Laboratorys comprehensive
stool analysis also looks at the type of fungal/yeast overgrowth and advises
which anti-fungal is the most appropriate to eradicate it.
Consultant Clinical Psychologist in Paediatrics at the
John Radcliffe Hospital in Oxford
Dr Richer suggested we give our children attachment security through holding
to make them feel as secure as possible. We must interact at a basic level
and try to involve them as much as possible in simple tasks. Always redirect
aggression and try to introduce different tasks or items.
He suggested avoiding the following foods:
and other grains not rice
in Experimental Gastroenterology in the Departments of Medicine and Histopathology
at Royal Free University College Medical School
Dr Wakefield has found that 52% of the autistic children tested have lymphoid
nodular hyperplasia. This is seen in the colon and terminal ileum and
not higher up in the gut. Immunologically, he noted that their IgG1 levels
in these children were raised suggesting a TH2 elevation and that their
CD3 were lower than normal. He feels that this lymphoid hyperplasia is
Professor of Oral Medicine and Chairman of the Division
of Oral Medicine, Pathology, Microbiology and Immunology at the new Guys,
Kings and St Thomass Medical and Dental school.
Why aren't we all allergic to food? The reason is that we have developed
an intolerance to foods. Oral tolerance is caused by specific immunological
unresponsiveness induced by feeding antigens.This can cause intestinal
hypersensitivity to food allergens and may also provide vital clues for
the treatment of many inflammatory disorders. The mucosal epithelium is
protected predominantly by IgA antibodies and oral tolerance can lead
to an inhibited production of IgE and IgG antibodies. If there is evidence
of allergens then all will be elevated. The induction and effector sites
on the mucosal immune system are:
Tonsils, adenoids +NAL
GALT (peyers patches in ileum)
Upper respiratory tract
and B cells carry IgA antibodies to all mucosal epithelial sites to protect.
TH1 is suppressed by oral tolerance especially if there is a high dose
of allergens and TH2 is increased. Therefore the risk of more allergens
produced is higher. T cells are important for producing cytokines IL2,3,4,5,10
and interferon-y. These, especially IL4 and 10, are important cytokines
in making us tolerant against allergens.
Professor of Microbiology at University of Reading
was concluded that yeast overgrowth and parasitic infestation are opportunists
and will soon become dominant within the gut. If there is a deficiency
then the good gut flora must be replaced using probiotics to improve the
gut balance. The beneficial gut flora are:
is developing a prebiotic that is a non-digestible food ingredient that
boosts the already present bacteria. Probiotics have to be taken in large
quantities if they are to reach the gut. Acid resistant forms are the
best. More information is available from Bio Care in Birmingham (see advert
on inside back cover for contact details).
When using anti-fungals especially nystatin, bifidobacteria numbers are
suppressed so use a probiotic to supplement the gut.
Professor of Clinical Paediatric Immunology at Great
Ormond Street Hospital for Children
Professor Strobel mentioned the great 8 food sources from
which allergies generally come:
oral tolerance is when the food enters the gut and primes the immune system
to respond by producing a mucosal response. When a food enters the gut
and there is an immune exclusion or deviation then there is antigen exposure.
If this is inherited genetically then there will already be exposure to
these antigens and therefore the child remains allergic to the foods that
enter its gut.
There are immediate responses to some antigens. These can be seen on the
skin where a skin test is positive. Some take longer through abdominal
pain, bloatedness, diarrhoea etc when a skin test is negative. Other responses
may cause a multitude of disorders which affect the skin, lungs, GI tract
and the central nervous system. These allergens can create havoc with
the balance of the immune system with the TH2 cells in particular being
elevated. Due to these allergens irritating mucosal surfaces IgA levels
If the mother already has a high number of allergens then the child may,
through pregnancy, be exposed to TH2 immune disregulation during their
If this is the case the child may be a late birth and be more susceptible
to increased risk of allergy.
Reader in Human Toxicology at the School of Biosciences,
University of Birmingham.
is an altered biochemistry in autism seen in
per cent of autistic children come from parents with dyslexia, development
disorder, eczema and asthma, learning difficulties, hyperactivity and
Dr Waring sees the sulphur transferases as not working properly. This
affects the neurotransmitters and therefore brain function, thought pattern
etc. Autistic children have little or no sulphation due to low sulphur
transferase enzyme levels or the inability to activate them. Foods that
inhibit these enzymes are: oranges, spinach, radishes, grapefruit, beetroot,
peppers, pumpkins and tomatoes. Other foods that inhibit sulphation are
bananas, cheese and chocolate.
Cysteine amino acid, along with sulphur containing foods, is important
as a sulphate provider for the body to utilise. Cysteine oxidase is the
enzyme that produces sulphate and the ratio of cysteine/free sulphate
in blood plasma should be tested. In normal children the ratio is 1-100
and in autistics it is 1-500, so there seems to be a definite deficiency
here. The average plasma sulphate level is 4.9 in normal children but
0.49 in autistic children.
Sulphate (SO4-2) is important for the production of mucin proteins, steroids,
bile acids, phenols, cholecystokinin, catecholamines and the formation
of connective tissue.
Mucin protein production is very important. If there is a deficiency in
sulphation there are known links with gut dysfunction and irritable bowel.
There must be enough sulphur attached to these proteins otherwise the
gut wall will allow peptides through.
Cholecystokinin (cck-8) protein allows the gut to be linked with the brain
structure. This stimulates the secretion of enzymes, gastric acid and
gall bladder contraction. It also controls food intake.
Sulphation must also be present for digestive hormones to function properly.
Gastrin must be sulphated to release active pepsin. Pepsin activates secretin
release and cholecystokinin, which when sulphated, stimulates the pancreas
to release pancreatic enzymes.
My question: If there is no sulphation, protein digestion will therefore
be impaired making the gut more permeable. Could this be the reason why
peptides are discovered in the urine?
My comment: There is a simple test to check the sulphate levels in the
urine conducted at Biolab in Wimpole Street, W1. If they find sulphate
then you know it isnt being utilised properly. If the family has
a history of migraine and allergy these are caused through a deficiency
in sulphurtransferase and in turn this could lead to autism in children.
This for me, was the most interesting of talks as it addressed the primary
functioning of the body, its biochemical activity.
Director of the Autism Research Unit at Sunderland.
Shattock again gave a very brief look at the findings in opoid peptides
in the urine of autistic children and spoke of a more recent finding (trans)
indoyl-3-acryloylglycine (IAG). He has discovered that 80% of autistic
children have raised levels of IAG as well as elevated levels of casein
He came up with a simple to do list.
pH levels, consider betaine HCL and ensure supplement levels are correct
Repair gut wall (use evening primrose oil)
sulphate (put a cup full of epsom salts in the bath)
methylsulphonyl methane suppl ‡ement
low phenolic foods.
a gluten and casein free diet
sulphur utilising foods
have tried to summarise the presentations as simply as possible. It was
a wonderful day and I urge those of you who are interested to attend and
support these conferences. They quite possibly hold the keys to finding
a solution to the problem of autism. I feel we have the experts who can
find out what has caused this epidemic and if supported and managed as
an interactive unit, they will succeed in finding a cure. I personally
feel we are not too far away!